CREB and the CRTC co-activators: sensors for hormonal and metabolic signals
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متن کاملBipartite functions of the CREB co-activators selectively direct alternative splicing or transcriptional activation.
The CREB regulated transcription co-activators (CRTCs) regulate many biological processes by integrating and converting environmental inputs into transcriptional responses. Although the mechanisms by which CRTCs sense cellular signals are characterized, little is known regarding how CRTCs contribute to the regulation of cAMP inducible genes. Here we show that these dynamic regulators, unlike ot...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2011
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm3072